was _gaq = _gaq
Monday, September 20, 2010
Where To Buy A Harry Potter Scarf In Toronto
Researchers at the California Institute of Technology (Caltech) have created a new program to kill cancer cells. The process developed by Niles Pierce, associate professor of applied and computational mathematics and bioengineering at Caltech, and his colleagues have used small RNA molecules that can be programmed to attack only specific cancer cells, then, changing shape, these molecules induce the cells that cause the cancer to destroy itself. In conventional chemotherapy treatments for cancer, patients are given drugs that the typical behavior of the target cell, but unfortunately are not exclusive only of tumor cells. For example, commonly used drugs commonly attack the cells that divide rapidly accelerated since that division is a hallmark of most cancer cells.
Unfortunately, the rapid cell division is a property of normal cells present in the bone marrow, digestive tract and hair follicles, and so these cells are killed, leading to a series of debilitating side effects ( in short, the aim of chemotherapy is to kill cancer cells before these drugs causing too much damage to the patient). "A method best,-says-Pierce, would be to develop drugs that are able to distinguish cancer cells from the healthy ones and then, once these cells have been identified, mark them for destruction, in other words, produce molecules that can "diagnose" what are the cancer cells before eradicating them. "
This type of therapy may negate the side effects associated with conventional chemotherapy. It could also be adapted to the molecular level to the individual types of cancer. The research has been published on
. But we see a little more closely what it is, the research carried out by research theme uses molecules of RNA with a hairpin structure, small RNAs that are less than 30 base pairs in length. (An average gene consists of thousands of base pairs). The method used by the researchers' involves the use of two different varieties of small RNA. One of the molecules is designed to be complementary, and therefore able to bind to a specific sequence of RNA of a particular cancer cell, for example, the cells of glioblastoma, an aggressive brain tumor. In order to bind to the cancer mutation, the RNA hairpin to open the molecule changes from one shape into another, which in turn, exposes a sequence that can bind spontaneously to the second type of RNA hairpin. The opening of the second hairpin reveals a sequence that binds to the first type of hairpin, and so on.
In this way, the identification of tumor markers active self-assembly of these RNA molecules that leads to the formation of a long polymer double-stranded RNA. This causes the cell innate immune response very similar to what occurs in the presence of viral RNA. In fact, the human cells to defend against the infection of a virus using a protein called protein kinase R (PKR) 
to search long strands of viral RNA, double strand, which should not be present in healthy human cells. If the PKR detects these strands of RNA inside a cell, the protein activates a process of apoptosis (programmed cell death) to remove cells.
The little trick is to form double-stranded RNA molecules similar to the virus, as if the cell was invaded by a virus to search long strands of viral RNA, double strand, which should not be present in healthy human cells. If the PKR detects these strands of RNA inside a cell, the protein activates a process of apoptosis (programmed cell death) to remove cells. ,
causing it to trigger a cell death process " says Pierce. "However, there is no 
virus."
virus." 
Subscribe to:
Post Comments (Atom)
0 comments:
Post a Comment