ribonuclease A new study uncovers the molecular mechanisms controlling gene expression in lung cancer RB2/p130.
var _gaq _gaq = Sbarro Health Research Organization Center for Biotechnology Research (SHRO), a center for cancer research in a nutshell, located in the College of Science and Technology at Temple University in Philadelphia, PA, and at the University of Siena in Italy examined the control mechanisms that determine gene expression in lung fibroblasts RB2/p130 and characterizing the effects of deregulation in the characteristics of RB2/p130 proliferative cell lung cancer. More importantly, their findings seem to have revealed that the gene is expressed differently in small cell lung cancer and in the non-small cell. Saturday, March 12, 2011
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The new findings reveal the mechanism of control of gene expression in lung cells RB2/p130 , involving two proteins are relatively new, the CCCTC
factor (binding factor for 
CTCF) and Boris (CTCF-equivalent). "
Our research shows that CTCF and Boris epressione directly regulate the gene in lung cells RB2/p130," explains Marcella Macaluso, Ph.D., an author of the study
. "We found that in small cell lung cancer RB2/p130 the expression levels were low, while in non-small cell lung cancer is overexpressed compared to normal cells of the lung. However, until now, there has been insufficient and conflicting data that does not allow us to connect the deregulation of dell'epressione RB2/p130 with the mutation of this gene in the cells of lung cancer. This study has finally revealed the mechanism and the actors that control the expression of RB2/p130, and these results have high potential to provide important information for understanding the anti-proliferative and proliferative signals triggered by RB2/p130 
Our research shows that CTCF and Boris epressione directly regulate the gene in lung cells RB2/p130," explains Marcella Macaluso, Ph.D., an author of the study .
In addition, research shows that RB2/p130 is engaged in a complex web of interactions with DNA methyltransferase (DNMTs) and other proteins, including CTCF and Boris, who are involved in epigenetic control of chromatin organization and transcription. This complex network of proteins appears to regulate cellular senescence - or aging - that is a very powerful anti-cancer mechanism.
Our studies may provide new insights into the molecular pathways that are active and correlated with the expression of RB2/p130 can be used as new biomarkers for early detection of lung cancer and / or predictors to determine the effect of treatment of cancer and be used for the development of clinical therapies based on modulation of RB2/p130, CTCF and / or expression of BORIS,
"says Dr. Macaluso. 
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