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I've got the power to kick your ass!

I feel strong. I am mistress of myself, sure of my ideas and proud of the choices I made and I will do. I feel satisfied when, after receiving puzzled looks in front of my motorcycle jacket and my sweatshirt worn, head-on step in front of the nth bunch of ignorant paesanotti surface. My father still has financial problems, my mother's love is still on the bottom of the bottles of wine and the school is always the same oppressive and repressive madhouse, but there were clear improvements. First the philosophy lessons are free and each day more interesting, because fortunately our teacher is not one of those who are maniacally obsessed from strict compliance with the program and then leave us discuss and explore issues that concern us most. And it's a man with an immense culture and speak with him is quite challenging, even though I prefer to listen to him, because he always finds a way to amaze and fascinate me. Another good thing is my friendship with Tiziana in reality is not new, it's just one of my dearest friends and I really like about her. Tiziana is my classmate and has beautiful blue eyes indigo. Can play the guitar and sings well, but the thing I most appreciate in her is an open mind: it has no prejudices, is not materialistic and do not currency it is that people as they appear outwardly. He has a particular personality and tends to be melancholy with ease, but a person creative and intelligent and that is why I consider it a true artist, the art of living. He has the courage to say and do the very things that most people, but wishing it does not say or do, and I think that is the envy of those people-wrongly-that give much importance to the opinions of others. I like to talk to her because I feel that both have the same need to understand and to try as many things as possible, and then she also has a free spirit, which is not made to submit to taxation or burdensome demands. It's a girl sensitive and sweet and I really need her to be happy to be myself. When there is not much I miss and when the morning gets late to school I always fear that will not and that I'll spend the morning putting up the boredom and banality of most lessons. This, when added to the immense love I feel for Beppe , fills my heart with joy and serenity. While I have the love of my love and my friend and the opportunity to study philosophy, I feel that I am strong and ready to tackle any difficulties.

White Discharge Sign Of Period

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These researchers have clarified the basic concepts biochemistry, with the help of ribonuclease, and were all rewarded with the Nobel Prize.

Fast and Aggressive

Ribonuclease A, shown above from the PDB file

5rsa

, is an endonuclease, which means that the RNA can cut inside (endo) of the chain. Other

ribonuclease degrade RNA from the extremities, such as' esosoma
which is involved in the degradation of RNA inside cells.

Ribonuclease A binds to the RNA chain in the large pocket that holds the center of the structure (see figure below from the PDB file 1rta) and attacks with a set of amino acids and bases. Ribonuclease A is an aggressive demolition molecular size very quickly after the RNA bases cytosine, or, though more slowly, after those of uracil. In the course of evolution, has become so efficient that belongs to that small group of enzymes whose activity is not limited by their speed of reaction, but the rate of diffusion of the molecules that must degrade.

strong as a rock Ribonuclease A is incredibly stable. For example, in one of the steps to purify the pancreatic ribonuclease A bovine extracts are treated with sulfuric acid and heated to near boiling, the ribonuclease protein is the only survivor. This is not surprising because it is an enzyme secreted by the pancreas and must act in the intestine where the environment is very inhospitable. The stability of ribonuclease A is due in large part to the four disulfide bonds that bind together different parts of the protein chain and help maintain a compact form.

precision cutting

Ribonuclease A is a powerful tool to cut the RNA into pieces, but the cells also need other tools to make some changes to their target RNA. For example, transfer RNA molecules are synthesized

longer than necessary and then must be trimmed to correct length.

The enzyme ribonuclease

Z, shown on the left, shortening the side chain that binds the amino acid. This structure contains the enzyme in its dimeric form (light blue and dark blue) and a stretch of two molecules of transfer RNA (orange).

The

ribonuclease P, which consists of two protein chains and a ribozyme (an enzyme made of RNA), shorten the chain on the other side (not shown here).

The

ribonuclease III, shown below, binds RNA sequences around the double helix and makes some specific cuts, necessary for the operation and regulation of ribosomal RNA and messenger.

explore the structure Ribonuclease A is a molecular machine dangerous to cells because it cuts across the board, which meets each RNA. E 'toxic for the cells to the point that has also been tested as anticancer drug. Unfortunately it proved not only toxic to cancer cells, but also for than normal and therefore its use in chemotherapy has been abandoned. The cells defend themselves by ribonuclease A (shown in blue) synthesizing potent inhibitors like the one shown in green (PDB file 1dfj). These inhibitors bind immediately to any ribonuclease A molecule that is able to enter the cell. The bond is very strong realized due to the large contact surface between the two molecules, because the inhibitor is almost completely wrapped around the ribonuclease.

Note the unusual structure of the inhibitor that has a very symmetrical crown with many portions outside the alpha helix (in red in the picture below) and folds into so many portions beta (Yellow).

's also interesting to note that the structure of the inhibitor is stabilized by interactions between nonpolar amino acid leucine (highlighted with the atoms in the form of small balls) that protrude abundant in the inner portion of the inhibitor between the helices and beta pleated structures as shown in the figure below.

Source: PDB,

proteopedia.

Multi In One Rb 539 Free Drivers

ribonuclease A new study uncovers the molecular mechanisms controlling gene expression in lung cancer RB2/p130.

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STEM CELLS ... AND IF THE REPROGRAMMING OF SOMATIC PROBLEMS?

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A particular news regarding stem cell research. As many will know the stem cells promise a huge step forward in regenerative medicine due to their ability to regenerate diseased or damaged tissues. A major problem in the use of stem cells is the conversion. In fact, the most sought after stem cells are embryonic cells, the specific nature of these cells is to be pluripotent.

What does this mean? Put succinctly, the stem cells are the precursors of all other types of cells in our body. These undifferentiated cells who have the ability to form any cell type, as well as have the ability to produce more stem cells. That is why stem cells are called progenitor cells. Now we can split the stem cells in pluripotent and multipotent: the first, as the embryonic ones, are capable of being able to differentiate into any cell type in the embryo and in adults, other multipotent stem cells are defined because they can differentiate into many types phones, but not all types. A cell is farthest from the zygote, children become the potential of this cell type. The question of how to obtain embryonic stem cells clearly raises questions insurmountable ethical, and not end up being exploited. Despite all the stem cells are used, especially if it makes extensive use of somatic stem cells ,

in many cases are called adult stem cells, although not necessarily arise from the adults. In any case, these cells are multipotent and as said before are not very versatile as embryonic, then we could say that are limited in their use, and this is when they have developed the techniques of cellular reprogramming. Through these techniques that is done, put very briefly, is to erase the memory cell to bring her to the molecular pluripotent state. In this way, the somatic stem cells should be able to be safely used instead of embryonic regenerative medicine.

An increased risk for cancer?

But a study has just been published in the journal Cell Death and differentation, reduces these hopes. The study conducted by the Department of Biochemistry at the University of Geneva and the European Institute of Oncology in Milan, with the participation of the laboratory Throne shows that in many cases, the reprogrammed stem cells showed some degree of "genomic instability", which seems to be caused by the process used to return the cells to "embryonic state". What seems even more serious is that the genetic changes observed are similar to those found in cancer cells. Scientists have concluded that the reprogramming of stem cells needs to be fully investigated before the cells can be considered for use in regenerative medicine. The experiments were performed using mammalian cells and mouse fibroblasts. The researchers used three different processes for the reprogramming of cells to a "root", or embryonic state. The first method was developed specifically for this study, and others are already been well documented. Should follow some of the articles in Nature.
Yet all processes lead to the same conclusion: genetic abnormalities multiplied, in a way that suggests that they are inherent to the process of genetic reprogramming stessa.Anomalie that seem similar to those caused by oncogenes. These findings underscore the need to conduct further studies. First, see if the genetic abnormalities are severe enough to affect the functioning and stability of regenerated through the reprogrammed cells, and second, "

refine the methods used to generate pluripotent cells induced in order to avoid this problem. "

Source: Eurekalert